Ozempic Constipation: Causes, Relief, and Prevention Tips That Work (2026)
Introduction Constipation is the most common side effect of Ozempic (semaglutide). You lose weight, your blood sugar improves, but your bowels stop cooperating. It is frustrating, uncomfortable, and , left unmanaged , it can derail your treatment. The numbers from clinical trials tell the story. In the STEP 1 trial , the landmark study that established semaglutide 2.4 mg for weight loss , approximately 24% of participants reported constipation, compared to roughly 11% in the placebo group [1]. In STEP 2, which studied people with both obesity and type 2 diabetes, the rate was similarly high at about 22% [2]. Across the broader GLP-1 receptor agonist class, systematic reviews consistently place constipation among the top three gastrointestinal complaints, alongside nausea and diarrhea [3,4]. ...