Person feeling tired with Ozempic medication concept art

Tired on Ozempic? Here is why and what you can do about it

Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Fatigue can have many causes, some of which require medical evaluation. Always consult your healthcare provider about persistent fatigue or other concerning symptoms while taking any medication. Fatigue doesn’t get the same attention as nausea when people talk about Ozempic side effects, but it’s surprisingly common. In the STEP 1 trial, about 11% of people on semaglutide reported fatigue, compared to 5% on placebo PMID: 33567185. Online forums are full of people asking some version of “why am I so tired on this medication?” ...

July 4, 2026 · 9 min · 1800 words · GLP-1 Guide Medical Team